DNA interstrand cross-links promote chromosomal integration of a selected gene in human cells.
نویسندگان
چکیده
منابع مشابه
A new antitumor antibiotic, FR-900482: V. Interstrand DNA-DNA cross-links in L1210 cells.
FR-900482 (Fig. 1) is a new antitumor antibiotic isolated from the culture broth of Streptomyces sandaensis No. 68971~3). It has potent cytotoxic effects against murine and human tumor cells2>4), and weak myelosuppressive effects in mice5). The mechanisms by which FR-900482 induces cytotoxic effects have not been defined. Some antitumor drugs induce interstrand DNA-DNA cross-links or DNA strand...
متن کاملStructure of a DNA glycosylase that unhooks interstrand cross-links.
DNA glycosylases are important editing enzymes that protect genomic stability by excising chemically modified nucleobases that alter normal DNA metabolism. These enzymes have been known only to initiate base excision repair of small adducts by extrusion from the DNA helix. However, recent reports have described both vertebrate and microbial DNA glycosylases capable of unhooking highly toxic int...
متن کاملInterstrand cross-links generated by abasic sites in duplex DNA.
Abasic sites (1, Scheme 1), which are generated by hydrolysis of the glycosidic bonds connecting the heterocyclic nucleobases to the deoxyribose backbone, represent the most common type of damage suffered by genomic DNA.1 Spontaneous hydrolysis yields approximately 10,000 abasic sites per cell per day. In addition, exposure of DNA to radiation, mutagens, and anticancer drugs can lead to the gen...
متن کاملRearrangement of interstrand cross-links into intrastrand cross-links in cis-diamminedichloroplatinum(II)-modified DNA.
In the reaction of the anticancer drug cis-diamminedichloroplatinum(II) (cis-DDP) with DNA, bifunctional intrastrand and interstrand cross-links are formed. In this work, we show that at 37 degrees C interstrand cross-links (ICL) are labile and rearrange into intrastrand cross-links. The ICL instability was first studied with a 10 base pairs (bp) double-stranded oligonucleotide containing a uni...
متن کاملSchizosaccharomyces pombe checkpoint response to DNA interstrand cross-links.
Drugs that produce covalent interstrand cross-links (ICLs) in DNA remain central to the treatment of cancer, but the cell cycle checkpoints activated by ICLs have received little attention. We have used the fission yeast, Schizosaccharomyces pombe, to elucidate the checkpoint responses to the ICL-inducing anticancer drugs nitrogen mustard and mitomycin C. First we confirmed that the repair path...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1989
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.9.7.2897